Post COVID 19 Complex

The global impact of the novel coronavirus, severe acute respiratory syndrome, and the infection that caused COVID-19 has become evident in the past few months, from unprecedented socioeconomic shocks to more than 1,000,000 deaths.

Due to the rapid release of free radicals and cytokines, patients with coronavirus experience significantly increased oxidative stress, which leads to damage and subsequent cell death. (Source)

As of today, the new coronavirus has been quite well studied and its ability to quickly mutate, change and develop new ways to enter the cells of our body has been proven, causing tremendous damage to important internal organs (lungs, heart, blood vessels, liver and brain). The virus causes a long-term imbalance in the work of not only the immune system, but also other important systems of our body.

Consequences of the work of the central nervous system and brain

Although many people infected with SARS-CoV-2 have no symptoms or develop respiratory symptoms, extrapulmonary manifestations, including neurological symptoms, are increasingly being found. Viruses can enter the CNS in a variety of ways, including the vasculature, olfactory and trigeminal nerves, cerebrospinal fluid, and lymphatic system. However, the exact route by which SARS-CoV enters the central nervous system has not yet been established. (Source) It is important to understand that 80% of the cerebrospinal fluid comes from the blood, and the rest of the cell is synthesized and released by the central nervous system. 

Neurological manifestations are widespread in COVID-19 patients, ranging from mild complications such as dizziness and headaches to severe complications such as encephalopathy, encephalitis, Guillain-Barré syndrome (GBS), anosmia, acute cerebrovascular disease, and ischemic stroke. (Source) Changes in oxygen metabolism found in the brains of patients with COVID-19 have been described. In fact, SARS-CoV-2 can cause oxygen deprivation in neuronal cells in the brain. (Source)

Since SARS-CoV-2 antibodies develop rapidly after infection, damage to the nervous system through the immune response can occur after a viral infection. The circulation of the virus in the bloodstream, its interaction with the capillary endothelium and the subsequent formation of viral particles can determine the destruction of the capillary endothelium of the brain, allowing the virus to enter the brain. The destruction of the endothelium of the capillaries of the brain and hemorrhage into the brain tissue can be fatal. (Source)

Damage to the liver and gastrointestinal tract

Coronaviruses, including SARS-CoV-2, are strongly associated with respiratory symptoms during infection, but gastrointestinal symptoms such as diarrhea, vomiting, nausea, and abdominal pain have been reported in selected subgroups of COVID-19 patients. These symptoms can have important implications for the treatment, rehabilitation and prognosis of the disease, especially in patients with pre-existing concomitant diseases of the liver or digestive system. Evidence suggests that the gastrointestinal tract is a viral target for SARS-CoV-2 infection. In addition, the viral balance in the gastrointestinal tract can be disrupted during SARS-CoV-2 infection, which can further affect the intestinal microflora. It should also be noted that testing treatments, including antiviral and antibacterial drugs, plasma transfusions and other dietary supplements from COVID-19, are detrimental to the digestive tract. (Source) All currently prescribed drugs for COVID-19 are metabolized in the liver. (Source)

In recent studies, the incidence of liver damage is indicated in 50% of cases of COVID-19 infection, mainly associated with ALT (alanine aminotransferase) and AST (aspartate aminotransferase) levels, accompanied by a slight increase in bilirubin levels. Higher rates of abnormal levels in severe COVID-19, reaching 78%. (Source)

Given the deep multisystem involvement of COVID-19, especially in severe and critical forms of the disease, liver damage is likely to be multifactorial, with the contribution of systemic inflammation, intrahepatic immune activation, microvascular thrombosis, liver congestion, and bowel dysfunction. (Source) These data suggest that coagulation dysfunction or damage may be a major trigger in the pathogenesis of liver damage associated with COVID-19. (Source)

COVID-19 and the immune system

Immunity is the cornerstone of human-virus interaction in any infectious disease. It includes three different but interrelated key aspects: vulnerability, immune response (defense) and potential immune pathology.

The immune system, which is affected by the virus, attempts to respond with a cytokine storm and hyperinflammation, which in itself leads to further damage to multiple organs and even death. Upon entry, the SARS-CoV-2 virus binds to human epithelial cells, activating the innate and adaptive immune systems, resulting in the release of cytokines. This systemic cytokine barrier disrupts the regulation of immune responses, which leads to the development of acute respiratory consequences. This increase in cytokines leads to severe inflammation throughout the body. (Source) 

Research shows that a sustained immune response to different types of cells is critical to recovery from Coronavirus Disease (COVID-19).

Vitamins and trace elements - help in treatment and recovery

A wealth of research points to the importance of various micronutrients in the interactions between the immune system and viruses, including COVID-19. There are complex and multifaceted relationships between micronutrient levels, immune response and viral activity. Trace elements and vitamins play a crucial role in the coordinated attraction of immune responses to viral infections, especially in the regulation of our body's anti-inflammatory responses. Additionally, micronutrient deficiencies not only weaken the immune system to fight off viral infections, but also contribute to more complex strains by altering the genetic makeup of the virus itself.(Source)

It is well known that nutrition can affect the immune system and its susceptibility to viral infection. Numerous studies have indicated an increased predisposition or severity to various viral infections in malnourished individuals. In addition to the response of the viral infection itself, various micronutrients can have a significant impact on the severity of the disease by modulating viral pathogenesis, such as mutations in the viral genome.

The addition of micronutrients to patients increased the number of T cells and lymphocytes, improved the response of lymphocytes to the causative virus, increased the levels and activity of immune cells, promoted the response to influenza vaccine, and reduced the duration of viral diseases. Some commonly used medications, such as antibiotics, can deplete various micronutrients such as iron and vitamins A, B, and D. The combination of micronutrient supplementation can reduce antibiotic use and cause higher levels of antibodies in the body after an illness. Interestingly, some countries with higher morbidity and mortality from COVID-19, such as Italy and Spain, have higher antibiotic consumption compared to other European countries. Studies have shown that mice treated with antibiotics are unable to independently stimulate the release of cytokines in the lungs and enhance the body's defenses after infection with the virus.

Scientists have absolutely proven that cells devoid of micronutrients (vitamins and trace elements) contribute to the emergence of new strains of viruses with new pathogenic properties. The deficiency of micronutrients in cells allows an increase in viral mutations, as well as enhances oxidative damage to the RNA genome.

The role of vitamins in both innate and adaptive immune response has been confirmed. Some vitamins, such as vitamins E and C, and some members of the B vitamin family, have antioxidant and various other effects on the immune system. Moreover, vitamins B and D, as immunomodulatory compounds, play a crucial role in the immune system. 

The role of melatonin in reducing the level of oxidative stress and inflammatory reactions has been studied and proven. Certain supplements can also improve the effectiveness of antiviral therapy and reduce drug toxicity.

These vitamins (for instance, vitamin C and D) and micronutrients (for instance, Selen) have shown antiviral potential in various experimental models and clinical trials. The results of these clinical trials will determine the precise role of these supplements as potential alternatives for better treatment of SARS-CoV-2 infection and recovery from illness. (source)

As can be seen from the above studies, the body weakened by the postponed coronavirus infection not only can, but also needs to provide vitamin support. Vitamins are the fastest and most effective method of eliminating the vitamin and mineral imbalance caused by Covid-19 and will help you recover in the shortest possible time, strengthen the immune system and return to an active lifestyle.

The postcovid complex has a beneficial effect on the most vulnerable organs and systems of the body. It eases the course of coronavirus infection and helps to recover from the disease.

Peptide bioregulators with vitamin complexes and minerals activate metabolic processes, targeting liver cells, thymus gland and neurons. They can be used as a means of prophylaxis, an auxiliary drug in complex therapy and rehabilitation after undergoing covid.

KHAVINSON PEPTIDES® technology has been used since 1973 and has a lot of research published on PubMed. Scientifically proven and effective.

Recommended for:

• strengthening the immune system;

• increasing immunity for colds, SARS;

• improvement of the condition in the postcovid period;

• recovery from severe infections;

• increasing the effectiveness of the main treatment.

Description:

The antiviral complex supports organs and systems that are most sensitive to the effects of viruses, which are the first to take the "blow" and resist the negative influence of pathogenic pathogens.

Benefits:

• proven lack of side effects;

• balanced composition of vitamins, peptides and minerals;

• directly affects organs and systems vulnerable to viruses;

• clinically proven efficacy of the components.

Mechanism of action

For the liver:

Peptide components in LIVPROTECT® have a targeted effect on liver cells, stimulating their regeneration, and also help to inactivate, that is, neutralize toxins, thereby increasing the barrier function of the organ. Liver cells are the first to suffer not only from viruses, but also from taking antibiotics and other drugs. Short peptides activate regenerative processes.

For the brain:

Short peptides in STRESSFOLL® improve metabolic processes in neurons - brain cells, accelerating their proliferation. Peptide bioregulators activate and maintain functional reserves, improving cognitive abilities and the general condition of the central nervous system.

The pineal gland peptide in the composition of the drug normalizes the hormonal background and supports the activity of the gland, thereby preventing the degenerative processes triggered by the coronavirus.

For immunity:

Peptide bioregulators and vitamin complex IMMUNGET® restore thymus cells that synthesize T-lymphocytes. These cells detect and destroy foreign antigens, including viruses, and also switch immunoglobulin isotypes, thereby adjusting to the destruction of new pathogens.

IMMUNGET® increases the reserve capacity of the immune system and accelerates the body's immune response, preventing viruses from entering the cells of organs and tissues and causing damage to them. In this way, it acts as a prophylactic agent that prevents the pathological process and provides a mild course of the disease caused by Covid-19. In complex therapy, it speeds up the healing process.

Application results

The result of the complex effect of peptide bioregulators and vitamins will be:

• normalization of liver function;

• improving digestion;

• increasing cognitive abilities;

• improving the activity of the central nervous system;

• strengthening the immune system and body defenses